![]() Compared to the HIDT cohort, the MSDT cohort had a higher 3-year cumulative incidence of relapse (CIR 47%, 95% CI, 31–63% vs. The cumulative incidence of positive MRD post-transplantation was 26% (95% CI, 19–33%) and 44% (95% CI, 28–60%) for HIDT and MSDT, respectively ( P = 0.043). ![]() We designed a prospective genetically randomized study to evaluate donor options between acute lymphoblastic leukemia (ALL) patients positive for measurable residual disease (MRD) pre-transplantation who underwent HIDT ( n = 169) or MSDT ( n = 39). Previous reports suggest a benefit associated with haploidentical donor transplantation (HIDT) compared to matched sibling donor transplantation (MSDT) in certain contexts, and the choice of optimal candidates warrants further investigation.
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